A flu season simulation
A simulation of one flu season in 10,000 US adults, with and without the flu vaccine.
What happens to 10,000 unvaccinated adults?
- Flu illness
- 0
- Hospital care
- 0
- Death
- 0
Fever, aches, and exhaustion, usually for several days.
Pneumonia or a serious worsening of heart or lung disease.
Mostly adults 65 and older.
Based on the average of CDC’s estimates for 13 flu seasons, 2010–2025, omitting the two COVID-19 seasons, applied to today’s US adults.
How it works
The simulation follows 10,000 US adults through one typical flu season, showing how many get sick with flu, how many need hospital care, and how many die. It then re-rolls the dice for the same people as if all had been vaccinated.
This is a Monte Carlo simulation: for each adult, we roll dice weighted by likelihood.
A typical season. The chances come from CDC’s estimates of flu illness, hospitalization, and death by age for 13 seasons from 2010–11 to 2024–25, averaged. The two COVID-19 seasons are excluded. The rates are adjusted to people who aren’t vaccinated and weighted to today’s mix of US adults by age, so older adults, who account for most flu hospitalizations and deaths, count in proportion.
The vaccine prevents about 40% of flu illness serious enough to see a doctor in a typical season, the median of CDC’s season-by-season estimates since 2010–11. The simulation applies the same 40% to hospital care and death, as CDC’s own analysis of vaccine benefits does.
Caveats. Real seasons vary widely, from mild to severe, and so does how closely the vaccine matches the flu strains circulating that year. The simulation shows an average season, not a forecast for this one or a personal risk estimate.
Sources
- CDC: Flu Disease Burden by Season and Age, 2010–11 to 2024–25 (data file)
CDC’s estimated flu illnesses, hospitalizations, and deaths by age for each season, with population. Averaged across 13 seasons from 2010–11 to 2024–25, omitting 2020–21 (no estimate) and 2021–22, adults 65 and older had about 520 flu hospitalizations and 55 flu deaths per 100,000 people per season; adults 18 to 49 had about 46 and 1.6. The 2024–25 estimates are preliminary.
- Chung et al., Effects of Influenza Vaccination in the United States During the 2018–2019 Influenza Season (Clin Infect Dis 2020)
CDC’s 2018–19 burden estimates by age. Hospitalizations per 1,000 illnesses: about 6 (18 to 49), 11 (50 to 64), and 91 (65 and older). Deaths per 1,000 illnesses: about 0.2, 0.6, and 8.3. Flu vaccination coverage that season was 35% (18 to 49), 47% (50 to 64), and 68% (65 and older).
- CDC: Past Seasons’ Vaccine Effectiveness Estimates
CDC’s season-by-season effectiveness estimates since 2010–11 range from 19% (2014–15) to 60% (2010–11), with a median of 40% across 15 seasons (the two most recent still marked preliminary).
- US Census Bureau: National Population by Characteristics, Vintage 2025
July 1, 2025 estimates of the US adult population: 144.2 million aged 18 to 49, 61.0 million aged 50 to 64, and 64.6 million aged 65 and older.